The lymphocyte monocyte ratio (LMR) and red blood cell distribution width (RDW) are being recognized as useful prognostic tools for patients with Diffuse Large B Cell Lymphoma (DLBCL).

We retrospectively analysed 98 data of DLBCL patients diagnosed between 2008 and 2018 from three hospitals in Porto Alegre/RS/Brazil and collected data form blood count cells and DHL.

Patients with LMR ≤1.90 were in advanced stage of the disease (Ann Arbor stages III and IV p = 0.011), had a high LDH (p < 0.001) and age ≤60 years (p = 0.026). Patients with RDW ≥14.25 were in advanced stage of the disease (p = 0.023) with these being older (6 years, p = 0.049). RDW and LMR showed significant prognostic of overall survival (OS) in univariate (p = 0.003 and p = 0.006) and multivariate analyses (p = 0.0018 and p = 0.021), respectively.

RDW and LMR are important independent prognostic factors. An elevated RDW and a decreased LMR are associated with a bad/worst prognosis in newly diagnosed DLBCL. RDW is the most adverse prognostic factor and could be included prognostic scores for DLBCL.