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Vol. 46. Núm. S4.
HEMO 2024
Páginas S973 (outubro 2024)
Vol. 46. Núm. S4.
HEMO 2024
Páginas S973 (outubro 2024)
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IS PERIPHERAL BLOOD STEM CELL MOBILIZATION VIABLE IN CROHN'S DISEASE PATIENTS UNDERGOING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION?
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MA Ruiza,b, RL Kaiser-Juniora,b, L Piron-Ruiza, LG Quadrosb, G Piron-Ruizc
a Associação Portuguesa de Beneficência de São José do Rio Preto, São José do Rio Preto, SP, Brazil
b Kaiser Clinica, Centro Médico Avançado de São Jose do Rio Preto, São José do Rio Preto, SP, Brazil
c Faculdade Faceres, São Jose do Rio Preto, SP, Brazil
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Vol. 46. Núm S4

HEMO 2024

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Background

Crohn's disease is a chronic, inflammatory disease of the gastrointestinal tract. As an autoimmune disorder, treatment with high doses of chemotherapy followed by autologous hematopoietic stem cell transplantation is promising for refractory Crohn's disease patients with no other therapeutic option and at imminent risk of further surgeries.

Objectives

To evaluate the feasibility and efficacy of hematopoietic progenitor cell mobilization in a group of Crohn's disease patients preparing for autologous unselected hematopoietic stem cell transplantation in a single institution. This is the first study to evaluate mobilization in Crohn's disease.

Methods

Patients were selected according to criteria of the European Bone Marrow Transplant Society.

Results

All patients mobilized with the mean number of hematopoietic progenitor cells obtained and infused being 16.17×106/CD34+/kg. Most (23/29) patients required only one leukapheresis session to reach the ideal number of cells. Grafting occurred around ten days after cell infusion. Complications and adverse events during the mobilization period were rare with only one patient presenting sepsis as a relevant event in the period. Most patients 20/29 (70%) had anemia from the beginning of the mobilization but only 11 (37.9%) received packed red blood cell transfusions.

Conclusion

Mobilization in patients with Crohn's disease is effective; almost all patients in this series were good mobilizers.

Clinical trial register

NCT 03000296.

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Idiomas
Hematology, Transfusion and Cell Therapy
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