von Willebrand disease (VWD) is the most common bleeding disorder due to a qualitative or quantitative disorder of von Willebrand Factor (VWF). There are three main types of the disease (types 1, 2, and 3) and a total of 6 subgroups. Type 1 patients present low levels of VWF; type 2 patients present low activity of VWF, and type 3 patients have a virtual absence of this VWF. VWD is the most common coagulopathy in the human population, but is the least diagnosed. Undiagnosed individuals may present symptoms that are often neglegted. The aim of this study was to analyze the quality of life of patients with VWD who are treated at Fundação Hemominas. Patients were invited to participate in consultations and examinations. The 30 patients included (17 women and 13 men) answered a 36-item brief health questionnaire (SF-36). The analysis of quality of life in women showed that the concept of physical functioning received a median (MED) of 82.5% (IQR 73.8%-95%); the concept of role limitations due to physical health received a MED of 100% (IQR 18.8%-100%); the concept of pain received MED of 61% (IQR 61%-84%); the concept of general health received MED of 77% (IQR 60.8%-88.3%); the concept of energy/fatigue received MED of 57.5% (IQR 33.8%-80%); the concept of social functioning received MED of 81.5% (IQR 25%-100%); the concept of emotional well-being received MED of 83.5% (IQR 33%-100%); and the concept of mental health received MED of 76% (IQR 34%-80%). In men, on the other hand, the analysis of quality of life showed that the concept of physical functioning received a MED of 90% (IQR 70%-100%); concept of role limitations due to physical health received a MED of 25% (IQR 0%-75%); the concept of pain received MED of 72% (IQR 50%-84%); the concept of general health received MED of 67% (IQR 47%-85%); the concept of energy/fatigue received MED of (IQR 50%-80%); the concept of social functioning received MED of 75% (IQR 38%-75%); the concept of emotional well-being received MED of 100% (IQR 67%-100%); and the concept of mental health received MED of 80% (IQR 68%-84%). After analyzing these data, it was not possible to find a significant difference between male and female patients. In conclusion, our study is important to better understand which aspects of quality of life are most impaired in patients with VWD. This study has some limitations because patients were not subdivided by VWD type, and no participants were genotyped yet. This is an ongoing study and the number of participants needs to be increased to draw conclusions. We thank all participants, Fapemig, Fundação Hemominas, and the CGSH of the Ministry of Health.