In the second half of April 2020, a new syndrome associated with SARS-CoV-2 infection,”multisystem inflammatory syndrome in children” (MIS-C), was defined by the World Health Organization.However, the risk factors that predispose some children to develop this inflammatory response are poorly understood .Determining the clinical risk factors of MIS-C is important in preventing undesirable complications such as death in children.

In this study, we aimed to investigate the effect of ABO blood groups, hematological parameters (white blood cell, absolute neutrophil, absolute lymphocyte, platelet count, prothrombin time, activated partial thromboplastin time), cardiac parameters (troponin, brain natriuretic factor, electrocardiography) of patients diagnosed with MIS-C in Ankara City Hospital during the pandemic shortening fraction, ejection fraction), infectious parameters (c-reactive protein, interleukin-6, sedimentation) were analyzed retrospectively.

Of our 89 cases, 49 (55.1%) were group A, 3 (3.4%) were group AB (3.4%), and 11 (12.4%) were group B. 60 of our patients presented with cardiac involvement, 14 with acute abdomen, 1 with seizure, and 1 with acute kidney injury. In clinically severe cases, MPV was higher and platelet count was lower. O blood group were diagnosed with MISC at a later age. Patients with A blood group have a statistically significantly less serious course compared to other blood groups.

In our study, we found that individuals with A blood group had MISC more frequently than other blood groups, and MISC was less severe in these patients compared to other blood groups.