Therapeutic plasmapheresis is an extracorporeal treatment method. The abnormal component of the patient's plasma is removed from the blood and replaced with the remaining blood components with a selected replacement fluid. We aimed to evaluate the demographic characteristics, procedure indications, procedure methods, differences between pre- and post-procedure laboratory parameters, and procedure-related complications of pediatric patients who underwent therapeutic plasma exchance (TPE).

Pediatric patients who underwent therapeutic plasmapheresis in Adana City Training and Research Hospital between 2018-2021 were included in our study. In this period, the number of pediatric patients who underwent therapeutic plasmapheresis was 61, and the total number of procedures was 238. The data of the patients were obtained from the files of the apheresis unit and the hospital registry system by retrospective analysis. Statistical analysis of the study was made with the SPSS v20 program.

25 patients were female, 36 patients were male. Youngest patient was 6 months old and eldest was 17 years old. Patients weight range was between 5 and 104 kilograms. 191 of the procedures were TPE, 47 of them were lipid apheresis. The most common indications were hepatic failure, familial hyperlipidemia, neurological disorders, hematological disorders, sepsis with MODS and intoxications. 119 transactions were in ASFA category-1. Complications were observed on 59 (%24,8) procedures.

The most common complications are; vascular access releated (obstruction) (21/59), hypotension (11/59), urticaria (7/59), technical malfunctions (7/59) and hypocalcemia (4/59). No exitus was observed due to the procedures. Therapeutic plasmapheresis procedure doesn't cause serious undesirable changes in laboratory values ​​and serious complications are rare. Therapeutic plasmapheresis can be safely applied to pediatric patients in appropriate indications by making necessary adjustments.