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Case report
We describe a five-year-old girl with high risk B precursor acute lymphoblastic leukemia with central nervous system involvement. Laboratory tests suggested the presence of central hypothyroidism (thyroid-stimulating hormone [TSH]: 0.30 mU/ml, normal range 0.64–6.27 mU/ml; serum free thyroxine [FT4]: 0.70 ng/dl, normal range 0.86–1.4 ng/dl). Magnetic resonance imaging detected heterogeneous contrast enhancement of pituitary gland in addition to cerebral and cerebellar atrophy.
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