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Vol. 44. Núm. S1.
Páginas S14-S15 (Outubro 2022)
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Vol. 44. Núm. S1.
Páginas S14-S15 (Outubro 2022)
OP 03
Open Access
AN UPDATED OF PIONEER PROJECT TO COLLECT DATA OF T-CELL NHL PATIENTS AMONG FIVE REGIONS OF BRAZIL. T-CELL BRAZIL PROJECT
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Carmino A De SOUZA1, Carlos S CHIATTONE2, Eliana MIRANDA1, Juliana PEREIRA3, Karyn Z CECYN4, Nelson S CASTRO5, Sergio A B BRAZIL6, Danielle F C FARIAS7, Marcelo BELLESSO8, Guilherme DUFFLES1, Davimar BORDUCCHI9, Yung GONZAGA10, Renata L R BAPTISTA11, Carolina C VILARIM12, Massimo FEDERICO13
1 University of Campinas – UNICAMP, Hematology and Hemotherapy Center, SP
2 Samaritano Hospital – Higienopolis & Santa Casa Medical School of Sao Paulo
3 Medicine School of University of São Paulo, USP
4 Federal University of Sao Paulo - UNIFESP
5 Cancer Hospital Barretos, Hospital de Amor, SP
6 Santa Casa Medical School of Sao Paulo
7 Hospital Beneficencia Portuguesa, SP
8 HemoMed, Instituto de Ensino e Pesquisa – IEP, São Lucas, SP
9 Medical School of ABC, Santo Andre, SP
10 Cancer National Institute – INCA, RJ
11 State University of Rio de Janeiro – UERJ & Instituto D'Or de Pesquisa e Ensino IDOR, RJ
12 Instituto de Ensino, Pesquisa e Inovação, Liga Contra o Câncer, CECAN, RN
13 University of Modena and Reggio Emília
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Objective

T-cell Brazil project started in April 2017 an ambispective study focusing to collecting epidemiological and clinical data from the most frequent subtypes of PTCL. Our goals are to obtain the frequency of subtypes by the five Brazilian macro regions; to investigate the clinical and biology characteristic; to create a routine pathological revision and to evaluate the OS, EFS in 5 years of follow-up.

Methodology

Thirteen nine centers had approved by their Ethical Committee and using REDcap Platform by Vanderbilt are registering their cases. Descriptive and bivariate analyses, then it was applied Kaplan-Meier method and log-rank test to obtain survival estimates, using IBM-SPSS v.24

Results

The median age was 55 years (19-95); 56% male; Almost 72% had advanced stages, 28% ECOG ≥ 2; the distribution of main subtypes was: 31% PTCL-NOS; 18% ALCL, ALK-; 16% ATL; 13% ENKTL nasal and nasal type; 11% AITL; 7% ALCL, ALK+; 6% others (Table 1). 50% of patients were alive and the 24-month PFS and OS was 36% and 50%, respectively. OS by main subtypes was 48% PTCL-NOS; 61% ALCL, ALK-; 33% ATL; 46% ENKTL nasal/nasal type; 48% AITL; 80% ALCL, ALK+.

Conclusion

This is the first experience cover all over the country, focusing also an educational and of interchanging experience network among the multidisciplinary health team in Brazil. The target of 500 was exceeded; however, the registry will go on until December as planned. All cases have been reviewed both in the registry and by pathologist Committee, and we esteem some cases will be excluded for different reasons and anyway it will help for future analyses if the number of registers is higher.

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Hematology, Transfusion and Cell Therapy
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