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Vol. 43. Issue S3.
Pages S16-S17 (November 2021)
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Vol. 43. Issue S3.
Pages S16-S17 (November 2021)
OP 04
Open Access
UPSHOTS IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA: ANALYSIS OF T-CELL BRAZIL PROJECT
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Carlos CHIATTONE1, Eliana MIRANDA2, Marcia DELAMAIN3, Juliana PEREIRA4, Natalia ZING5, Danielle FARIAS6, Guilherme DUFFLES2, Marcelo BELLESSO7, Nelson CASTRO8, Renata BAPTISTA9, Karin CECYN10, Suellen MO11, Yana RABELO12, Patricia RADTKE13, Sergio BRASIL14, Samir NABHAN15, Glaciano RIBEIRO16, Joao SOUTO-FILHO17, Vera FIGUEIREDO18, Rony SCHAFFEL19..., Maria DIAS20, Elizete NEGREIROS21, Eduardo RIBEIRO22, Massimo FEDERICO23, Carmino SOUZA24Ver más
1 Samaritano Hospital - Higienopolis, Sao Paulo, Brazil and Santa Casa Medical School, Sao Paulo, Brazil
2 Hematology and Hemotherapy Center at University of Campinas, Sao Paulo
3 Medical Sciences Faculty of Minas Gerais
4 Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology, Medicine School of University of Sao Paulo
5 Prevent Senior Hospital, Sao Paulo
6 Beneficiencia Portuguesa de Sao Paulo
7 Instituto Hemomed de Oncologia e Hematologia, Sao Paulo
8 Fundação Pio XII, Cancer Hospital of Barretos, Sao Paulo
9 Hematology Service, Faculty of Medicine, State University of Rio de Janeiro
10 Clinical and Experimental Oncology Department, Federal University of Sao Paulo
11 Samaritano Hospital - Higienopolis, Sao Paulo, Brazil
12 Clinical Hospital of Federal University of Goias
13 Casa de Saude Santa Marcelina, Sao Paulo
14 Santa Casa Medical School, Sao Paulo, Brazil
15 Hematology Department, Federal University of Parana
16 Clinical Hospital of Federal University of Minas Gerais
17 Medical Faculty of Campos dos Goytacases, Rio de Janeiro
18 Hospital do Servidor Público Estadual de Sao Paulo
19 Clementino Fraga Hospital, Federal University of Rio de Janeiro
20 Federal University of Bahia
21 Hospital de Amor da Amazonia, Fundação Pio XII, Rondonia
22 Hospital Santa Lucia, DF
23 University of Modena and Reggio Emilia, Italy
24 Medical Sciences Faculty of University of Campinas
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Vol. 43. Issue S3
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Objective

T-cell Brazil Project was designed as an ambispective data collection from January 2015 to December 2022 of previously untreated patients diagnosed with Peripheral T-cell lymphoma (PTCL) or NK/T-cell lymphoma according to the revised WHO 2017 classification in Brazil. The primary and secondary end points were 2-year overall survival (OS) and progression-free survival (PFS). Clinical, treatment and survival data were also correlated.

Methodology

Twenty centers got approved for the study from the local and national institutional review board and registered their cases only online. OS was calculated from diagnosis date until last seen or death date, whereas PFS until first event, progression / relapse, date of death or last seen. Kaplan-Meier method was applied and a Log-rank test to compare their curves. P-value less than 5% was considered. From a total of 416 patients with PTCL, 46 (11%) were diagnosed as AITL.

Results

The median age was 65 years (31-82), with 63% males, 94% had advanced-stage disease. All patients received 61% CHOEP, 28% CHOP and 11% CT without anthracycline. 20% of pts were consolidated with autologous transplant (HSCT). There were 19 (41%) deaths, 10 by lymphoma, 8 infections, 1 new neoplasia. With 8-mo median f/u (1-36), OS at 24-mo was 27% and 2-year PFS was 21%. As consolidation, OS was 71% HSCT group vs. 16% no HSCT (P= 0.06) and PFS was 71% vs. 8%, respectively (P= 0.01).

Conclusion

These analyses are preliminaries but show a poor outcome of AITL in our population. Most patients were treated with anthracycline-containing combination chemotherapy and just 20% received autologous HSCT. A dismal survival was shown for those who did not receive HSCT.

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Hematology, Transfusion and Cell Therapy
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