UNUSUAL METABOLIC COMPLICATIONS OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA: HYPERCALCEMIA, HYPERAMONEMIA, LACTIC ASIDOSIS

Kaçar, Dilek; Yılmaz, Aslı Turgutoğlu; Yozgat, Ayça Koca; Yaralı, Neşe

doi:10.1016/j.htct.2021.10.1079

Hematology, Transfusion and Cell Therapy

ISSN: 2531-1379

Hematology, Transfusion and Cell Therapy is a quarterly scientific publication of the Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH), Associazione Italo-Brasiliana di Ematologia (AIBE), Eurasian Hematology Oncology Group (EHOG), and Sociedade Brasileira de Oncologia Pediátrica (SOBOPE).

Hematology, Transfusion and Cell Therapy publishes original articles, review articles and case reports covering various areas in the field of hematology and hemotherapy. The journal was previously published, until 2016, as Revista Brasileira de Hematologia e Hemoterapia.

ISSN print: 2531-1379
ISSN online: 2531-1387

Published by Elsevier Editora Ltda, Rio de Janeiro, Brazil.

Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management.

Indexed in:

Web of Science, LILACS, SciELO Brazil, ESCI (Web of Science), Scopus, and PubMed/PMC

We present three children with precursor B acute lymphoblastic leukemia (ALL). The first one had malignancy associated hypercalcemia at diagnosis. The second one experienced hyperamonemia during induction. Both of them had been treated successfully. The last one had refractory leukemia and died because of lactic acidosis due to extensive infiltration of the liver by tumor cells. The rare but potential fatal metabolic complications of ALL needs high clinical suspicion and prompt treatment.

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