Objective: The aim of the study was to investigate the impact of nutritional status, comorbidity and performance status on patients with diffuse large B cell lymphoma (DLBCL).

Methodology: A retrospective study was conducted on DLBCL patients who was diagnosed in our centre between 2009–2018. The study included a total of 112 patients. Demographic and disease characteristics and labaratory test results were recorded. Overall and progression free survival were measured from these data. The methods for the assessments are Charlson comorbidity index for comorbidity, albumin level for nutritional status and ECOG score for performance status.

Results: The average age of the patients was found to be 62.63±15.16 years. The ECOG score of 65 patients (69.1%) is in the range of 0–1. The mean follow-up time of the patients was determined to be 25.24±25.11 (months), and at the end of the follow-up period, 64 patients (57.1%) were found to be alive. The median of 5-year PFS was 13.2 months, and the 5-year OS was 59.8%. Those with CCI-A score <4 and those with ≥4 were compared. PFS, OS and 5-year OS values of those with CCI-A >4 were found to be significantly lower than those with CCI-A score ≤4 (p<0.05). As a result of the Cox-Regression (Backward: LR method) analysis, ECOG and albumin values were found to be independent risk factors for both OS and PFS (p<0.05).

Conclusion: This study demonstrated that CCI-A, ECOG and nutritional status are independent prognostic markers for DLBCL patients. Initial evaluation of these patients should include all of these parameters which are easily available at the time of diagnosis.