Objective: The aim of study was to evaluate the demographic, clinical, laboratory, genetic and pathological features of the patients followed with the diagnosis of adult ALL in our center and to evaluate their contribution to the prognosis, treatment responses and overall survival rates of the patients and to contribute to the literature.

Methodology: A total of 116 patients diagnosed with ALL in our center between 2006–2018 were included in the study. Patients under 18 years of age and patients with active solid organ malignancies were not included in our study. The data of the patients were obtained by scanning the hospital computer automation system and patient files.

Results: Sixty-two of our patients are male and 54 are female. The mean age of the patients was 43.1 years. Twenty patients were T-ALL and 96 patients were B-ALL. In a quarter of patients, the Philedelphia chromosome was positive. 22 of our patients had standard risk and 94 had high risk class. Total survival rate was 52.6%. The mean total survival time was 41,4 months. 83.6% of the patients were in remission with induction therapy. Forty patients underwent allogeneic stem cell transplantation. There was no statistically significant difference between B-ALL, T-ALL and Ph+ ALL patients in terms of remission induction and survival. Tyrosine kinase inhibitors improved the prognosis of Ph+ ALL patients. In patients who received TKI treatment, the decrease in PCR values at the 3rd month was found to be a good prognostic factor. PCR monitoring is important in predicting prognosis in patients receiving TKI. The presence of severe fibrosis in the bone marrow (Grade 2–4) was found to be poor prognostic.

Conclusion: In our study, although the overall survival rate is consistent with the literature, it is evident that it is still insufficient. Therefore, more study and innovation are needed in the treatment of adult ALL.