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Vol. 42. Issue S2.
Pages 75 (November 2020)
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Vol. 42. Issue S2.
Pages 75 (November 2020)
124
DOI: 10.1016/j.htct.2020.10.125
Open Access
POOLED COHORT EQUATIONS RISK SCORE AMONG HAEMOPHILIA: TIME TO FORMALLY EVALUATE CARDIOVASCULAR RISK IN PEOPLE WITH HAEMOPHILIA
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R.M. Cameloa,b,c, B.P. Duarteb, M.C.B. Mourab, N.C.M. Costab, I.M. Costab, A.M. Vanderleib, T.M.R. Guimaraesb, C.C. Deelderc,d, S. Gouwc, S.M. Rezendea, J.V.D. Bomc,d
a Ciências Aplicadas à Saude do Adulto, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
b Fundação de Hematologia e Hemoterapia de Pernambuco (Hemope), Recife, PE, Brazil
c Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
d Centre for Clinical Transfusion Research, Sanquin/Leiden University Medical Center, Leiden, Netherlands
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Brazil has the fourth largest haemophilia population in the world. All patients are followed at the haemophilia treatment centres, which provide them interdisciplinary care and replacement factor concentrates as part of the public health system. The mortality among Brazilian haemophilia people is decreasing and the relative incidence of cardiovascular (CVD) deaths is increasing. The aim of the current analysis of the HemoCardio Study was to describe the CVD risk score according to the Pooled Cohort Equations Risk (PCER) tool and its treatment recommendations. We included men with haemophilia 40 years or older. Patients who had previous CVD event or a low-density lipid cholesterol 5.0mmol/L or higher were excluded. Interviews, medical file reviews, and blood tests were performed. The PCER tool (www.cvriskcalculator.com) was used to estimate CVD risk, considering age, gender, race, total cholesterol, high-density lipid cholesterol (HDL), systolic and diastolic blood pressures, treatment for systemic arterial hypertension, diabetes and smoking status. Among the 30 included patients, the median [interquartile range; IQR] age was 51.5 [IQR;46.0-59.5] years. The majority had haemophilia A, 43% were severe, 57% were on prophylaxis and 7% were inhibitor positive in the last year. The frequencies of obesity, current smokers, hypertension, diabetes, hypertriglyceridaemia, hypercholesterolaemia, and hypoHDLaemia were 20%, 13%, 67%, 24%, 14%, 47%, and 23%, respectively. Median PCER score was 6.9 [IQR;3.1-13.2], with 50% of the patients having a moderate-to-high risk. Statin use was suggested for 46% of the patients. Blood pressure was poorly controlled in 47% of the patients. In conclusion, almost half of the men with haemophilia had a moderate-to-high PCER score with strong recommendations to improve control of dyslipidaemia and blood pressure.

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Hematology, Transfusion and Cell Therapy

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