Red cells with cytoplasmic projections, resembling pincer-like cells, also known as mushroom- shaped red blood cells, as Figures 1 and 2, are usually associated with erythrocyte disorders, such as congenital dyserthropoietic anemias, hereditary spherocytosis associated with Banda-3 protein deficiency, disseminated intravascular coagulation, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura, kidney disease, microangiopathic hemolytic anemia, erythroleukemia and, more rarely, oxidative drug-induced hemolysis. However, a recent study have demonstrated a relationship between these cells and infection caused by Sars-CoV-2 in a pathophysiologic mechanism that possibly involves the occurrence of oxidative stress, which triggers progressive cascade of inflammation, known as citokines storm, that leads to red blood cell damage.1–3
Journal Information
Vol. 44. Issue 3.
Pages 462-463 (July - September 2022)
Vol. 44. Issue 3.
Pages 462-463 (July - September 2022)
Images in Clinical Hematology
Open Access
Mushroom-shaped red blood cells (pincer cells): a brief update
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Guilherme Dienstmanna,
, Vitor Barbosa dos Santosb, Samuel Ricardo Comarc
Corresponding author
guidbio@gmail.com
Corresponding author at: Rua João Alexandre de França St., 349, CEP: 89225-140 Joinville, SC, Brazil.
Corresponding author at: Rua João Alexandre de França St., 349, CEP: 89225-140 Joinville, SC, Brazil.
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References
[1]
D Gérard, S Ben Brahim, JF Lesesve, J Perrin.
Are mushroom-shaped erythrocytes an indicator of COVID-19?.
Br J Haematol, (2021), pp. 230
[2]
JF. Lesesve.
Mushroom-shaped red blood cells in protein band-3 deficiency.
Am J Hematol, 86 (2011), pp. 694
[3]
SR McCann, R Firth, N Murray, IJ. Temperley.
Congenital dyserythropoietic anaemia type II (HEMPAS): a family study.
J Clin Pathol, 33 (1980), pp. 1197-1201
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