Journal Information
Vol. 43. Issue S3.
Pages S24 (November 2021)
Share
Share
Download PDF
More article options
Vol. 43. Issue S3.
Pages S24 (November 2021)
OP 22
Open Access
MANAGEMENT AND OUTCOMES OF NEUTROPENIA IN PREVIOUSLY HEALTHY CHILDREN
Visits
853
Hatice Mine Cakmak1, Omer Kartal2
1 Eskisehir City Hospital
2 Gulhane Research And Training Hospital
This item has received

Under a Creative Commons license
Article information
Special issue
This article is part of special issue:
Vol. 43. Issue S3
More info
Objective

Immun-component children with moderate neutropenia do not have an increased risk for severe bacterial infections. However, there is limited data for the management of benign neutropenia in children. Therefore, we aimed to determine the most common etiology and outcomes in children with neutropenia. In addition, we compare the laboratory findings of different severity levels (neutrophil levels <0.2 × 10³/mL, 0.2 × 10³-0.5 × 10³/mL, 0.5 × 10³- 1 × 10³/mL, 1 × 10³- 1.5 × 10³/mL).

Methodology

This retrospective study included children with neutropenia (neutrophil < 1.5 × 10³/mL) diagnosed between December 2019-November 2020 in a tertiary hospital. The patients aged between one month-eighteen year had no history of chronic disease, immunosuppressive therapy, malignancy, or drug administration. Ministry of Health's ethics committee approved the study. We evaluated the etiologies and compared age, sex, time of follow-up, duration of neutropenia, thrombocyte, monocyte and immunglobulin levels of neutrophil levels (<0.2 × 10³/mL, 0.2 × 10³-0.5 × 10³/mL, 0.5 × 10³- 1 × 10³/mL, 1 × 10³- 1.5 × 10³/mL).

Results

The most common etiology was acute neutropenia (81.5%) and infections (66%). Five (2.5%) had coronavirus disease. Chronic and autoimmune neutropenia are the most common in chronic neutropenia. Lower neutrophils are associated with prolonged neutropenia (p=0.003), higher monocyte (0.03), higher IgM levels (0.038), younger ages (p<0.001), higher IgG (p=0.002) levels. Sex, time of follow-up, thrombocyte levels, total IgE levels are similar in children with different neutrophil counts.

Conclusion

Our study demonstrates the etiology in children with neutropenia. The most common etiology is acute neutropenia with infections. In SARS-CoV2 diseases, neutropenia is less common than other hematologic findings. However, we detected in two point five percent of all. Unknown etiologies are also seen in the acute setting. Immun neutropenia and chronic idiopathic neutropenia are the leading causes of chronic cases. IgM levels were higher than the standard ranges in the agranulocytosis group, with a mean age of 1,05 ± 0,80. Therefore, children with ages of one-two should be carefully checked and followed for immunodeficiencies.

Full text is only aviable in PDF
Idiomas
Hematology, Transfusion and Cell Therapy
Article options
Tools