IS THERE AN ASSOCIATION BETWEEN PULMONARY EMBOLISM AND THE USE OF PEG-ASPARAGINASE IN CHILDREN WITH LEUKEMIA?

Orulluoğlu, Emine Yılmaz; Kaya, Zühre; Yazol, Merve; Turkcan, Büşra Topuz; Kayalı, Serap Kirkiz; Koçak, Ülker

doi:10.1016/j.htct.2023.09.077

Hematology, Transfusion and Cell Therapy

ISSN: 2531-1379

Hematology, Transfusion and Cell Therapy is a quarterly scientific publication of the Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH), Associazione Italo-Brasiliana di Ematologia (AIBE), Eurasian Hematology Oncology Group (EHOG), and Sociedade Brasileira de Oncologia Pediátrica (SOBOPE).

Hematology, Transfusion and Cell Therapy publishes original articles, review articles and case reports covering various areas in the field of hematology and hemotherapy. The journal was previously published, until 2016, as Revista Brasileira de Hematologia e Hemoterapia.

ISSN print: 2531-1379
ISSN online: 2531-1387

Published by Elsevier Editora Ltda, Rio de Janeiro, Brazil.

Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management.

Indexed in:

Web of Science, LILACS, SciELO Brazil, ESCI (Web of Science), Scopus, and PubMed/PMC

We present two leukemic children who developed pulmonary thromboembolism (PTE) after using PEG-asparaginase.The first child, an eight-year-old boy, was diagnosed with T-acute lymphoblastic leukemia (ALL). The second child, a 6-year-old boy, was diagnosed with B-ALL.They developed PTE following induction phases of BFM protocol's.They were given PEG-asparaginase at a dose of 2500IU/m2. Heparin was succesfully used in both cases.Physician may consider prophylactic anticoagulants during induction.

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