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Vol. 43. Issue S3.
Pages S60 (November 2021)
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Vol. 43. Issue S3.
Pages S60 (November 2021)
PP 73
Open Access
EVALUATION OF VACCINATION RESPONSE IN CHILDREN AFTER TREATMENT FOR ACUTE LEUKEMIA
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Elif KILIC KONTE1, Ayca KOCA YOZGAT2, Aysun KARA UZUN2, Bahar CUHACI CAKIR3, Hüsniye Nese YARALI2
1 Muş State Hospital
2 Ankara City Hospital
3 Gazi University Medical Faculty Hospital
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Vol. 43. Issue S3
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Objective

Our study aims to evaluate the patients’ immunity regarding childhood vaccination after leukemia treatment and determine the vaccines that require additional doses.

Methodology

Sixty-six patients who were followed up with the diagnosis of ALL and AML between 2013 and 2016 were included in our study. The patient's gender, age at diagnosis, leukemia type, leukemia risk groups, vaccination status before chemotherapy (CT) and serologies of hepatitis A, hepatitis B, varicella, measles, rubella, mumps at the end of CT were recorded.

Results

At the end of the treatment, loss of protective antibody response against hepatitis A (47.4%), hepatitis B (68.2%), varicella (64.2%), measles (45.5%), rubella (43.9%), and mumps (50%) vaccines were shown. Loss of protective antibodies against hepatitis A (66.7%), hepatitis B (100%), varicella (100%), measles (100%), rubella (91.7%), and mumps (91.7%) in high-risk ALL patients was higher than patients in standard-intermediate risk ALL.

Conclusion

Loss of humoral immunity against hepatitis A, hepatitis B, varicella, MMR was shown in patients with leukemia at the end of the treatment. Due to the significant decrease in hepatitis B and MMR protective antibodies in the high-risk group, we recommend patients with leukemia who have completed chemotherapy to be vaccinated with hepatitis B vaccine three months and MMR vaccine six months after the treatment.

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Hematology, Transfusion and Cell Therapy
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