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INIBIDORES FARMACOLÓGICOS DE IGF1R-IRS1/2 ATUAM POR MECANISMOS DISTINTOS E REVELAM VULNERABILIDADES PARA O TRATAMENTO DA LMA
J.L. Coelho-Silvaa,b, D.A. Pereira-Martinsb, V.C. Silvestrinib,c, J.A. Machado-Netod, E.M. Regob,e, M. Smolkaf, V.M. Façab,c, F. Trainaa,b
a Departamento de Imagens Médicas, Hematologia e Oncologia Clínica, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brasil
b Centro de Terapia Celular, Fundação de Amparo à Pesquisa do Estado de São Paulo, Ribeirão Preto, SP, Brasil
c Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brasil
d Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo (USP), São Paulo, SP, Brasil
e Divisão de Hematologia, Laboratório de Investigação Médica em Hematologia Molecular (LIM-31), Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brasil
f Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, Estados Unidos
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