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RESULTS OF THE PEGASUS PHASE 3 RANDOMIZED TRIAL DEMONSTRATING SUPERIORITY OF THE C3 INHIBITOR PEGCETACOPLAN COMPARED TO ECULIZUMAB IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
H. Weitza, P. Hillmenb, J. Szerc, A. Röthd, B. Höchsmanne, J. Pansef,g, K. Usukih, M. Griffinb, J. Kiladjianh, C. Decastroi, H. Nishimorij, L. Tank, M. Hamdanil, P. Deschateletsl, C. Francoisl, F. Grossil, A. Risitanom, R.P. Latourn
a Jane Anne Nohl Division of Hematology, Keck-USC School of Medicine, Los Angeles, United States
b Department of Haematology, St James's University Hospital, Leeds, United Kingdom
c Department of Clinical Haematology, Peter MacCallum Cancer Centre & Royal Melbourne Hospital, Melbourne, Australia
d Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
e Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service and University Hospital Ulm, Ulm, Germany
f Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany
g NTT Medical Center Tokyo, Tokyo, Japan
h Centre d’Investigations Cliniques, Hôpital Saint-Louis; Assistance Publique–Hôpitaux de Paris; Université de Paris, Paris, France
i Duke University School of Medicine, Durham, United States
j Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
k Lisa Tan Pharma Consulting Ltd, Cambridge, United Kingdom
l Apellis Pharmaceuticals, Waltham, United States
m Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy
n French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Assistance Publique–Hôpitaux de Paris, Université de Paris, Paris, France
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