PARP1 IS DIFFERENTIALLY EXPRESSED IN BCR-ABL P190+ ALL PATIENT SAMPLES AND TARGETING PARP INHIBITION INDUCES CELL DEATH COMPARABLE TO THAT OF TYROSINE-KINASE GOLDEN STANDARD IN PRE-CLINICAL MODELS
CB Machadoa, WAS Ferreirab, FMCP Pessoaa, FAR Mell-Júniorc, AD Seabrac, RM Ribeirod, MO Morae-Filhoa, MEA Moraesa, LEB Souzae, CFA Moreir-Nunesa,f,g
a Department of Medicine, Pharmacogenetics Laboratory, Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Ceará (UFC), Fortaleza, Brazil
b Laboratory of Cytogenomics and Environmental Mutagenesis, Environment Section (SAMAM), Instituto Evandro Chagas (IEC), Ananindeua, Brazil
c Molecular Biology Laboratory, Hospital Ophir Loyola (HOL), Belém, Brazil
d Department of Hematology, Hospital Geral de Fortaleza (HGF), Fortaleza, Brazil
e Centro de Terapia Celular (CTC), Fundação Hemocentro de Ribeirão Preto (FUNDHERP), Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, Brazil
f Department of Biological Sciences, Oncology Research Center, Universidade Federal do Pará (UFPA), Belém, Brazil
g Rede Nordeste de Biotecnologia (RENORBIO), Universidade Estadual do Ceará (UECE), Fortaleza, Brazil
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