TY - JOUR T1 - High frequency of primary refractory disease and low progression-free survival rate of Hodgkin's lymphoma: a decade of experience in a Latin American center JO - Hematology, Transfusion and Cell Therapy T2 - AU - Jaime-Pérez,José Carlos AU - Gamboa-Alonso,Carmen Magdalena AU - Padilla-Medina,José Ramón AU - Jiménez-Castillo,Raúl Alberto AU - Olguín-Ramírez,Leticia Alejandra AU - Gutiérrez-Aguirre,César Homero AU - Cantú-Rodríguez,Olga Graciela AU - Gómez-Almaguer,David SN - 15168484 M3 - 10.1016/j.bjhh.2017.08.001 DO - 10.1016/j.bjhh.2017.08.001 UR - http://www.htct.com.br/pt-high-frequency-primary-refractory-disease-articulo-S1516848417301056 AB - BackgroundReports dealing with clinical outcomes of classical Hodgkin's lymphoma in low- to middle-income countries are scarce and response to therapy is poorly documented. This report describes the characteristics and clinical outcomes of patients with classical Hodgkin's lymphoma from a single institution in Latin America. MethodA retrospective study was conducted over ten years of patients with classical Hodgkin's lymphoma treated at a referral center. Progression-free and overall survival rates were estimated by Kaplan–Meier analysis. The univariate Cox regression model was used to estimate associations between important variables and clinical outcomes. Main resultsOne hundred and twenty-eight patients were analyzed. The mean age was 28.5 years. The five-year progression-free and overall survival were 37.3% and 78.9%, respectively. Of the whole group, 55 (43%) were primary refractory cases. Only 39/83 (47%) patients with advanced disease vs. 34/45 (75.6%) in early stages (p-value=0.002) achieved complete remission. Those with advanced disease had a five-year overall survival of 68.7% vs. 91.8% for early disease (p-value=0.132). Thirty-one patients relapsed (24.2%) and 20 (64.5%) received a transplant. The hazard ratio for progression with bone marrow infiltration was 2.628 (p-value=0.037). For death, an International Prognostic Score ≥4 had a hazard ratio of 3.355 (p-value=0.050) in univariate analysis. Two-thirds of classical Hodgkin's lymphoma patients diagnosed at advanced stages had a low progression-free survival but an overall survival similar to high-income countries. ConclusionPatients diagnosed with classical Hodgkin's lymphoma in Northeastern Mexico had a significantly low progression-free survival rate and presented with advanced disease, underscoring the need for earlier diagnosis and improved contemporary therapeutic strategies in these mainly young productive-age Hodgkin's lymphoma patients. ER -