TY - JOUR T1 - Everolimus as a single agent in refractory or relapsed Hodgkin's lymphoma: the Brazilian Named Patient Program Experience JO - Hematology, Transfusion and Cell Therapy T2 - AU - Rocha,Talita Máira Bueno da Silveira da AU - Fortier,Sergio Costa AU - Fischer,Thais Rodrigues da Cunha AU - Perini,Guilherme Fleury AU - Gaiolla,Rafael Dezen AU - Fogliatto,Laura AU - Delamain,Marcia Torresan AU - Costa,Andressa Fragoso da AU - Castro,Nelson Siqueira de AU - Barretos,Wolney Gois AU - Souza,Cármino Antonio de AU - Buccheri,Valéria AU - Chiattone,Carlos Sérgio SN - 15168484 M3 - 10.1016/j.bjhh.2017.03.008 DO - 10.1016/j.bjhh.2017.03.008 UR - http://www.htct.com.br/pt-everolimus-as-single-agent-in-articulo-S151684841730049X AB - BackgroundDespite all the scientific progress that has been made on understanding the disease, prognosis for patients with relapsed and refractory Hodgkin's lymphoma remains poor and the treatment is palliative in the majority of the cases. Thus, the aim of this study was to present the results on the compassionate use of everolimus in a group of patients who were monitored at nine different centers in Brazil. MethodsA 10-mg oral dose of everolimus was given to each patient daily. Response time was evaluated from the beginning of medication use until loss of response, toxicity or medical decision to cease treatment. ResultsThirty-three patients were evaluated. The median age at the beginning of medication administration was 29 years. Patients had received a median of five prior therapies. Overall response rate was 45.4%, with 13 patients achieving partial response, two achieved clinical response, 14 remained with stable disease, two had disease progression, and two were not evaluated. Patients received a median of 14 cycles. Progression-free survival was nine months, and overall survival was estimated to be 36 months. Three patients used the medication for more than four years. The most frequently reported adverse events were thrombocytopenia and hypercholesterolemia. Three patients had pulmonary toxicity. Grade III and IV adverse events occurred in 39% of the patients. ConclusionEverolimus was found to provide a response in a group of patients with refractory or relapsed Hodgkin's lymphoma who had adequate tolerability to the drug. ER -