TY - JOUR T1 - Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia JO - Hematology, Transfusion and Cell Therapy T2 - AU - Belisário,André Rolim AU - Sales,Rahyssa Rodrigues AU - Toledo,Nayara Evelin AU - Velloso-Rodrigues,Cibele AU - Silva,Célia Maria AU - Viana,Marcos Borato SN - 15168484 M3 - 10.1016/j.bjhh.2016.09.017 DO - 10.1016/j.bjhh.2016.09.017 UR - http://www.htct.com.br/pt-interleukin-10-haplotypes-are-not-associated-articulo-S1516848417300233 AB - BackgroundThe etiology of stroke, a severe complication of sickle cell anemia, involves inflammatory processes. However, the pathogenetic mechanisms are unknown. The aim of this study was to evaluate the influence of interleukin-10 polymorphisms and haplotypes on the risk of acute cerebral ischemia and high-risk transcranial Doppler in 395 children with sickle cell anemia from the state of Minas Gerais, Brazil. MethodsInterleukin-10 haplotypes were determined by polymerase chain reaction-restriction fragment length polymorphism and sequencing. The outcomes studied were acute cerebral ischemia and high-risk transcranial Doppler. Clinical data were retrieved from the children's records. ResultsThere was no statistically significant difference in the frequencies of polymorphisms and haplotypes between children with and without acute cerebral ischemia or children with or without high-risk transcranial Doppler. These data are consistent with a previous report that showed an absence of association between interleukin-10 plasma levels and high-risk transcranial Doppler velocity in children with sickle cell anemia. ConclusionInterleukin-10 haplotypes were not associated with the risk of acute cerebral ischemia or high-risk transcranial Doppler velocity in children with sickle cell anemia from the state of Minas Gerais, Brazil. ER -