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Vol. 42. Issue S1.
Pages 71 (October 2020)
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Vol. 42. Issue S1.
Pages 71 (October 2020)
PP 64
Open Access
The course of toxic hepatitis at the stage of treatment consolidation acute leukemia in children
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M. Babayev*, A. Ahmadova, K. Mehtiyeva, N. Babayeva
National Hematology and Transfusiology Center, Moscow, Russian Federation
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Objective: Toxic hepatitis occupies a special place among the complications of chemotherapy in the treatment of patients with acute leukemia. The research work we have presented is devoted to studying the frequency of toxic hepatitis and the choice of treatment tactics for children who are at the stage of consolidating acute leukemia.

Methodology: The study group included 110 children from both sexes who reached complete remission after a course of induction. Patients were 9 months old up to 15 years. The treatment was carried out according to the Moscow-Berlin-2015 program, where the consolidation phase was composed of 3 courses of 8 weeks. The severity of toxic hepatitis was predetermined by its criteria.

Results: According to the data obtained, 81 patients had toxic hepatitis (73.6%). In mild form it was noted in 46 children (56.7%), in moderate severe in 31 (38.4%), and in severe in 4 children (4.9%).

Conclusion: In the mild form of hepatitis from the intravenous use of Essentiale forte and Riboxin against the background of ongoing chemotherapy, a positive effect was obtained. With moderate severity, intravenous administration of Adeomethionine preparations (Heptral/Legend) in combination with Aevit per os turned out to be more effective. In 4 patients, upon transition to a severe form in the last course of consolidation, along with these drugs, ursodeoxycholic acid (Ursobil)+enhanced detoxification therapy was prescribed, which led to a complete recovery. After the treatment of toxic hepatitis, all patients with moderate and severe form, for the purpose of prevention, was prescribed combination therapy with Ursobil+Aevit+Lipoic acid, which gave a long-term positive effect.

Idiomas
Hematology, Transfusion and Cell Therapy
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