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Vol. 42. Issue S1.
Pages 69-70 (October 2020)
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Vol. 42. Issue S1.
Pages 69-70 (October 2020)
PP 61
Open Access
The course of intracranial bleeding in the patient with immune thrombocytopenia
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M. Babayev*, A. Ahmadova, K. Mehtiyeva, N. Babayeva
National Hematology and Transfusiology Center, Moscow, Russian Federation
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Objective: The approach to the treatment of immune thrombocytopenia always remains relevant, despite the fact that the etiology and pathogenesis of the disease is quite clear, and it is clear that the development of the disease is based on the conflict between their own platelets and autoantibodies directed at them. The goal of treatment is to resist the creation of autoantibodies, protect your own platelets and lengthen their life. The proposed standards of treatment with steroids, reticuloendothelial system blockers, anti-lymphocytic antibodies, thrombopoietin, etc.did not find a clear place for a radical change in the course of the disease.

Case report: The article presents a case of a child suffering from chronic ITP who received various medical treatments with periodic remissions for 6 years. At the age of 10, the child had convulsions and neurological disorders due to acute respiratory infection and high temperature. In blood tests: PLT-10×109/L. CT scan of the brain showed the presence of intracranial bleeding. The prescribed “pulse therapy” with dexamethasone and platelet transfusions allowed for intracranial surgery (PLT – 234×109/L).). However, a few days later, due to the ineffectiveness of “pulse therapy”, and the risk of renewed bleeding, the patient was again transfused platelet mass and prescribed high-dose intravenous immunoglobulin (IVIG), which raised the platelet level to 210×109/L. Soon, this therapy was ineffective, and we had to re-transfuse the platelet mass and simultaneously prescribe thrombopoietin (Revoleyd). Against the background of this therapy, the platelet level was stabilized, and the resulting effect was long-lasting. At the moment, the child's hematological and neurological status is quite satisfactory.

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Hematology, Transfusion and Cell Therapy
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