The ASFA Journal of Clinical Apheresis (JCA) Special Issue Writing Committee is charged with reviewing, updating, and categorizing indications for the evidence-based use of therapeutic apheresis every 3 years to produce “Guidelines on the Use of Therapeutic Apheresis in Clinical Practice: Evidence-Based Approach” which is published in the Journal of Clinical Apheresis. Guideline preparation incorporates systematic review published peer reviewed literature and applies evidence-based approaches in the grading and categorization of apheresis indications. These guidelines serve as a key resource to guide the utilization of therapeutic apheresis in the treatment of human disease. In this session, we will review the evolution of the guidelines and highlight significant changes in the 2019 Journal of Clinical Apheresis 8th Special Issue published in June 2019. Recommendations for the use of therapeutic apheresis for Hematology/Oncology Indications will be briefly reviewed.