TY - JOUR T1 - Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research JO - Hematology, Transfusion and Cell Therapy T2 - AU - Ferdowsi,Shirin AU - Abbasi-Malati,Zahra AU - Pourfathollah,Ali Akbar SN - 25311379 M3 - 10.1016/j.htct.2020.10.963 DO - 10.1016/j.htct.2020.10.963 UR - http://www.htct.com.br/en-leukocyte-reduction-filters-as-an-articulo-S2531137920313043 AB - IntroductionPeripheral blood leukocytes are a suitable cell model for science research. However, blood samples from healthy volunteers are limited in volume and difficult to obtain due to the complexity of volunteer recruitment. ObjectiveTherefore, it is urgent to find an alternative source of peripheral blood leukocytes. MethodOne of the possibilities is the use of leukocyte reduction filters (LRFs) in blood banks that is used for preparation of leukoreduced blood products. More than 90% of the leukocytes are trapped in the leukofilters allowing the desired blood product to pass through. ResultsIt has been reported that the biological function of leukocytes collected from the filters are no different from those isolated from buffy coats, leukapheresis products and whole blood (WB) cells. Moreover, LRFs are waste products that are discarded after leukoreduction. ConclusionThus, leukofilters represent an economic source of human cell populations that can be used for a variety of investigative purposes, with no cost. In the present study, we reviewed the different usage of LRFs in the research, clinical and commercial applications. ER -